β-Lactamase Inhibitor NXL104 Helps Overcome Resistance of Pathogens
نویسندگان
چکیده
منابع مشابه
The β-lactamase inhibitor avibactam (NXL104) does not induce ampC β-lactamase in Enterobacter cloacae
Induction of ampC β-lactamase expression can often compromise antibiotic treatment and is triggered by several β-lactams (such as cefoxitin and imipenem) and by the β-lactamase inhibitor clavulanic acid. The novel β-lactamase inhibitor avibactam (NXL104) is a potent inhibitor of both class A and class C enzymes. The potential of avibactam for induction of ampC expression in Enterobacter cloacae...
متن کاملIn vitro activity of the β-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases
BACKGROUND NXL104 is a novel-structure beta-lactamase inhibitor with potent activity against both class A and class C enzymes. Among the class A carbapenemases, KPC-type enzymes are now spreading rapidly and KPC-related carbapenemase resistance is an emerging phenomenon of great clinical importance. The activity of NXL104 against KPC beta-lactamases was examined. METHODS Enzymatic activity of...
متن کاملIn vitro activity of ceftazidime+NXL104 against Pseudomonas aeruginosa and other non-fermenters.
BACKGROUND NXL104 potentiates ceftazidime and ceftaroline against Enterobacteriaceae with extended-spectrum, AmpC, KPC and OXA β-lactamases. We examined whether similar potentiation was obtained against non-fermenters, which are less permeable than Enterobacteriaceae and have more potent efflux. METHODS MICs of ceftazidime+NXL104 (with NXL104 at 4 mg/L) and comparators were determined by CLSI...
متن کاملDetection of β-lactamase-mediated resistance
ß-Lactams are the most widely used antibiotics, and ß-lactamases are the greatest source of resistance to them. Colorimetric tests are good, rapid, indicators of ß-lactamase production and its contingent resistance in Haemophilus, Moraxella and Neisseria spp. They can also be applied to Gram-negative bacilli but are less useful, since the usual question is not whether a ß-lactamase is produced ...
متن کاملAmpC β lactamases in Urinary Klebsiella pneumoniae Isolates: First Report of ACC Type AmpC β-lactamase Resistance in Iran
Background & Objective: The production of plasmid-mediated AmpC beta-lactamases (PMABLs) among urinary Klebsiella pneumoniae isolates causes a severe problem to the successful treatment of urinary tract infections (UTIs). This study was designed to evaluate antimicrobial resistance, the presence of AmpC beta-lactamase genes, and the genetic relatedness among K. pneumoniae strains separated from...
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ژورنال
عنوان ژورنال: Microbe Magazine
سال: 2011
ISSN: 1558-7452,1558-7460
DOI: 10.1128/microbe.6.107.1